Educational Materials

VIDEOS

View our video depicting the role of methotrexate polyglutamation and the utility of Avise PG^SM testing
View videos of Rheumatologists sharing their experiences with Avise personalized medicine services
Professional medical education presentations - hosted by Dr. Joseph Shanahan
- Avise PG^SM video (23 minutes)
- Avise MCV^SM video (7 minutes)

SCIENTIFIC INFORMATION

Switching From Oral to Parenteral Methotrexate Administration Produces Clinical Improvements Throught Selective Accumulation of Long-Chains Methotrexate Polyglutamates

CLINICAL SCENARIOS

MTX Optimization in Combination - Deciding to change dosage form
for methotrexate (MTX)
MTX Dose Optimization - Considering methotrexate (MTX)
dose adjustment
MTX Adherence - Establishing a baseline level of
methotrexate (MTX) polyglutamates (PGs)
MTX Exposure - Reassurance when advancing
to a biologic DMARD

PATIENT EDUCATIONAL MATERIALS

Review Patient Education Brochure for Avise PG
Review Patient Education Brochure for Avise MCV

PUBLICATIONS

Below you will find links to abstracts for key publications relating to Avise Personalized Medicine Services. If you are interested in speaking with a representative about article reprints, please contact our client services at 888.452.1522.

Methotrexate Polyglutamates Publications

Dervieux T, Furst D, Lein DO, Capps R, Smith K, Walsh M, Kremer J, Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis, Arthritis Rheum. 2004; 50(9):2766-2774.
(review abstract)

Dervieux T, Furst D, Lein DO, Capps R, Smith K, Caldwell J and Kremer J,
Pharmacogenetic and metabolite measurements are associated with clinical status in patients with rheumatoid arthritis treated with methotrexate: results of a multicentred cross sectional observational study, Ann Rheum Dis. 2005; 64(8):1180-1185 (review abstract)

Dervieux T, Greenstein N, and Kremer J, Pharmacogenomic and metabolic biomarkers in the folate pathway and their association with methotrexate effects during dosage escalation in rheumatoid arthritis, Arthritis Rheum. 2006; 54(10):3095-3103 (review abstract)

Kremer J, Toward a better understanding of methotrexate, Arthritis Rheum. 2004; 50(5):1370-1382. (review abstract)

Anti MCV Publications

Bang H, Egerer K, Gauliard A, Lüthke K, Rudolph PE, Fredenhagen G, Berg W, Feist E, Burmester GR, Mutation and citrullination modifies vimentin to a novel autoantigen for rheumatoid arthritis, Arthritis Rheum. 2007; 56(8):2503-11 (review abstract)

Mathsson L, Mullazehi M, Wick MC, Sjöberg O, van Vollenhoven R, Klareskog L, Rönnelid J, Antibodies against citrullinated vimentin in rheumatoid arthritis: higher sensitivity and extended prognostic value concerning future radiographic progression as compared with antibodies against cyclic citrullinated peptides, Arthritis Rheum. 2008; 58(1):36-45 (review abstract)

Innala L, Kokkonen H, Eriksson C, Jidell E, Berglin E, Dahlqvst SR, Antibodies against mutated citrullinated vimentin are a better predictor of disease activity at 24 months in early rheumatoid arthritis than antibodies against cyclic citrullinated peptides, J Rheumatol. 2008; 35(6):1002-8 (review abstract)

Ursum J, Nielen MM, van Schaardenburg D, van der Horst AR, van de Stadt RJ, Dijkmans BA, Hamann D, Antibodies to mutated citrullinated vimentin and disease activity score in early arthritis: a cohort study, Arthritis Res Ther. 2008; 10(1):R12. (review abstract)