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Avise SLE

Having difficulty diagnosing rheumatic diseases?
Avise SLE can help!

Avise SLE is a 5-marker panel consisting of serological and flow cytometric tests performed using a standard blood specimen, and shipped to our specialized laboratory for processing. Specifically, the panel includes testing of the following markers:

  1. ANA (anti-nuclear antibodies)2 — a negative result helps
    rule-out SLE
  2. dsDNA (anti-double stranded DNA antibodies) — a positive result helps rules-in SLE
  3. AVISE MCV (anti-mutated citrullinated vimentin antibodies) — to help rule-out Rheumatoid Arthritis
  4. EC4d

    Using cell-bound complement fragments to
    help rule-in SLE because of their increased
    performance over soluble complements which
    helps to accurately and consistently diagnose SLE    3


  5. BC4d

 



Avise SLE is a 30% improvement over the current standard of care.

To learn more about Avise SLE please contact our Client Services group at 888.452.1522 or click one of the links below or at right to view more Avise SLE information:

   i      Avise SLE Benefits

   ii.    Clinical Utility & When to Order
   iii.   CB-CAPs Technology
   iv.   Avise SLE Validation
   v.    Benefits of Whole Panel (5-marker) Testing


Using the science above, Avise SLE is most impactful when ordered as a first step in patient treatment to help physicians with SLE diagnosis by providing:
  • Efficiency -- 5 individual markers, 1 blood draw
  • Confidence in SLE Diagnosis -- From a panel that rules-in SLE and rules-out other rheumatic diseases
  • Increased Accuracy -- Using CB-CAPs technology to achieve 78% sensitivity and 87% specificity for other diseases/97% specificity for normal/healthy patients.***
  • Convenience -- We provide kits, pay for shipping costs and return test results in 7 business days


Avise SLE Diagnostic Immunology:

  • ANA, dsDNA and AntiMCV are measured using ELISA*
  • EC4d and BC4d are measured using Flow Cytometry

Specimen Collection & Handling Details:

  • Serum (5ml Serum Separator Tube)
  • EDTA blood (10ml)
  • Avise SLE test requisition
  • Overnight shipping in pre-provided Avise kits equipped with frozen coolant cartridge
  • Turnaround time – 7 business days upon receipt
Overcome the current hurdles of SLE diagnosis and help your patients get the answers they deserve by ordering Avise SLE today!

1 - SLE has many common disease mimickers – Fibromyalgia (+ ANA), Sjogren’s syndrome, Dermatomyositis, Rheumatoid Arthritis, Primary antiphospholipid syndrome, Neoplasms (hematologic), Vasculitis, etc.
2 - In case of a negative ANA result using ELISA, indirect immunofluorescence is used.
3 - Liu C et al. Cell-bound Complement Biomarkers for Systematic Lupus Erythematosus: From Benchtop to Bedside. 2009; 164(2).
4 - Kalunian K et al. The Contribution of Cell Bound Comple- ment Activation Products to the Diagnosis of Systemic Lupus Erythematosus. American College of Rheumatology meeting, Chicago November 5th 2011 (presentation 597).
5 - Clinical Laboratory News, Nov 2011: vol 37, pg 1