AVISE CTD is a comprehensive autoimmune connective tissue disease (CTD) diagnostic tool that leverages the highest quality standards and scientific analysis to provide rheumatologists with actionable results.

AVISE CTD is a blood test that provides insight into the differential diagnosis among a host of challenging diseases to diagnose including:

– Lupus (SLE)
– Rheumatoid arthritis
– Sjögren’s syndrome
– Polymyositis and dermatomyositis
– Scleroderma/systemic sclerosis
– Anti-phospholipid syndrome
– Autoimmune thyroid disease – Hashimoto’s and Grave’s

Exagen Inc. is a patient focused and discovery driven commercial-stage life sciences company. We aid healthcare providers in the diagnosis, prognosis, and management of autoimmune conditions with the use of our next-generation laboratory testing.

Physicians interested in ordering AVISE CTD can request a sample preparation guide that provides easy-to-follow instructions and the required materials, including a prepaid shipping label, ice pack and insulated interior to protect the specimens in transit.

Specimen collection tubes can also be provided upon request.

To request a kit, call 888.452-1522 or email us at [email protected]

Patients interested in having the test performed should present our physician request letter to their doctor.

AVISE CTD results are provided to the ordering physician within 5 business days from receipt of the sample.

AVISE CTD was developed after 15 years of research by Exagen and collaborators.

View Validation Studies

AVISE CTD is intended to be used for patients who have clinical suspicion of CTD and SLE due to clinical manifestations or related serologies. AVISE CTD has also been found to have clinical utility in differentiating +ANA primary fibromyalgia from SLE.

SLE associated markers:
– EC4d & BC4d
– Anti-Smith
– Anti-dsDNA (by ELISA and confirmation by Crithidia)
– ANA (by ELISA and IIF)

Extractable Nuclear Antigens Antibodies associated with autoimmune conditions that cause lupus-like symptoms:
– Anti-SS-A/Ro
– Anti-SS-B/La
– Anti-Scl-70
– Anti-U1RNP
– Anti-RNP70
– Anti-CENP
– Anti-Jo-1

Markers associated with rheumatoid arthritis:
– RF IgM
– RF IgA
– Anti-CCP
– Anti-CarP

Markers associated with Antiphospholipid syndrome, a common condition associated with SLE:
– Anti-Cardiolipin IgM
– Anti-Cardiolipin IgG
– Anti-B2-GP 1 IgM
– Anti-B2-GP 1 IgG

Markers associated with autoimmune thyroid disease:
– Anti-Thyroglobulin
– Anti-Thyroid Peroxidase

In a multicenter study including 794 subjects, AVISE CTD demonstrated superior performance over ANA and anti-dsDNA with:

33% increased specificity over ANA
48% increased sensitivity over anti-dsDNA
In addition, AVISE CTD’s scientifically proven CB-CAPs technology has also demonstrated a 22% increased sensitivity over C3/C4.
Putterman C, et al. Lupus Science & Medicine. 2014.

Yes, Exagen offers a financial assistance program for low income and self-pay patients. For more information, please visit: AVISE Insurance and Billing