“I don’t know
what i have.”


Give your patients the answers they need with help from AVISE® CTD, the most advanced autoimmune testing available.


Outsmart Autoimmune Disease with AVISE® CTD

Diagnosing autoimmune diseases early is difficult

AVISE CTD is a powerful clinical tool designed to aid rheumatologists in the differential diagnosis of autoimmune connective tissue diseases (CTDs) that often have overlapping symptoms.

 
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Just Two Tubes Provide Powerful Insights

Powered by our patented Cell-Bound Complement Activation Products (CB-CAPs) biomarkers and advanced algorithm, AVISE CTD combines AVISE Lupus, a 10-marker diagnostic test designed to help rule-in or rule-out lupus, with a 23 marker CTD panel to aid in the differential diagnosis of other systemic rheumatic diseases.1

Here's how two tubes of blood can help you outsmart your patient's autoimmune disease:

1

Patented CB-CAPs Biomarkers

EC4d • BC4d

2

Proprietary Two-tier Algorithm

AVISE Lupus Index

3

Expanded Connective Tissue Disease Panel

RA • APS • MCTD • Sjögren's • Myositis • Systemic Sclerosis • Autoimmune Thyroid Disease



Patented CB-CAPs Biomarkers

AVISE Lupus, a component of AVISE CTD, is the only validated test that uses patented stable biomarkers of complement activation called CB-CAPs that have been proven to outperform standard diagnosis laboratory testing (SDLT) in the detection of SLE.

Test AUC
AVISE Lupus 0.91
CB-CAP BC4d 0.84
CB-CAP EC4d 0.82
Anti-dsDNA 0.79
Complement C3 0.73
Complement C4 0.72
AUC-Area Under the Curve
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Figure adapted from Putterman C, et al.1

Proprietary Two-Tier SLE Algorithm

Using CB-CAPs and other SLE-associated markers, AVISE Lupus employs an advanced two-tier algorithm and proprietary Index Value to help turn isolated data points into actionable information. Developed using multivariate logistic regression, the index result is plotted on a spectrum associated with the likelihood of the presence of SLE.1

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Expanded Connective Tissue Disease Panel

AVISE CTD — Specifically designed to provide clarity and confidence!

12 ENA markers

aid in differential
CTD diagnosis

RA panel

(including RF IgM, RF IgA,
Anti-CCP, & Anti-CarP) to
help rule-in rheumatoid
arthritis

Anti-Phospholipid
Syndrome biomarkers

help assess risk for thrombatic
events and/or pregnancy morbidity as well as guide
SLE diagnosis

Thyroid panel

aid in diagnosis of
Graves’ Disease & Hashimoto’s thyroiditis

Patient Focused. Discovery Driven.

In addition to improving physician diagnostic confidence, patients in the AVISE Lupus arm of the CARE study reported a reduction in their anxiety or depression levels at the 12-week follow-up, while patients in the SDLT arm reported a slight increase.2

WHO SHOULD BE CONSIDERED FOR AVISE® CTD?

  • Patients with clinical suspicion of a connective tissue disease
  • Patients who are ANA+ referrals
  • Patients with overlapping symptoms
  • ANA+ fibromyalgia patients suspected of autoimmune disease

Robust, real-world evidence confirms that AVISE testing enables decisive clinical action superior to the current standard of care (tANA) in the differential diagnosis for lupus.


Read the CAPSTONE study