Giving Patients the Answers They Need

Obtain Diagnostic Clarity with AVISE® CTD

Overlapping symptoms contribute to diagnostic uncertainty

Delays in diagnosis can lead to increased morbidity, higher mortality rates, and escalating healthcare costs. AVISE CTD addresses the challenge of overlapping symptoms by providing a comprehensive test to help you build the foundation for a diagnosis.   

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Just Two Tubes Provide Powerful Insights

With over 30 biomarkers carefully selected by rheumatologists for their diagnostic relevance, AVISE CTD helps improve diagnostic accuracy, reducing uncertainty and aiding in earlier diagnosis.  

Here's how two tubes of blood can help you give your patients the answers they need:

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CB-CAPs Biomarkers

EC4d • BC4d • TC4d

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Proprietary Two-tier Algorithm

AVISE Lupus Index

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Connective Tissue Disease Panel

RA • APS • MCTD • Sjögren's • Myositis • Systemic Sclerosis • Autoimmune Thyroid Disease • Lupus



Novel Biomarkers for Rheumatoid Arthritis

Approximately 30% of diagnosed RA and up to 50% of early RA cases are seronegative. The use of conventional and novel biomarkers in one assessment provides an opportunity to substantiate clinical suspicion of RA, aiding in earlier diagnoses and treatment.

AVISE CTD’s enhanced RA profile incorporates conventional biomarkers (anti-CCP and RF) and new biomarkers (anti-RA33 and anti-PAD4) that are specific and sensitive to RA even in patients who test negative for anti-CCP and RF.

Anti-CarP autoantibody testing can be added to AVISE CTD to further enhance diagnostic profiles in seronegative and early RA cases.

Rheumatoid Arthritis
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AVISE® CTD Includes Novel Biomarkers and the Lupus Index Score

New T Cell Biomarkers for Systemic Lupus Erythematosus

Conventional SLE biomarkers such as anti-dsDNA, anti-Smith, and complement C3/C4 have limited discriminatory power characterized by poor sensitivity in incipient cases.

Newly available T Cell bound complement and autoantibodies have superior diagnostic accuracy when conventional biomarkers are uninformative, facilitating earlier diagnoses and treatment decisions.

T Cell Biomarkers
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Proprietary Lupus Algorithm

AVISE CTD employs an advanced two-tier algorithm and proprietary Index Value to convert isolated data points to an index score, which reports the serologic likelihood of the presence of SLE.

This multi-marker algorithmic assay integrates CB-CAPs and autoantibody levels to provide a diagnostic result that is both sensitive and specific for an SLE diagnosis. 

Lupus Algorithm

Biomarkers Included in AVISE® CTD

AVISE CTD Tier 2 Positive Sample Test Report
Download the report

Build Confidence With Reliable Results

Exagen has extensive peer-reviewed literature supporting the clinical utility of its proprietary technology, demonstrating actionable results that support your diagnostic and treatment decisions.